A small meteor crashes, with a symbiote inside. Meanwhile, an escaped convict Flint Marko falls into a lab pit and turns into sand. His former best friend Harry Osborn does not talk to him anymore and he has a new rival in the Daily Bugle: Eddie Brock. He defeats the bombers of the building and saves a woman from being killed. The game starts off as Spider-Man swings into a burning building. Hulk (Bruce Banner) (Mentioned in out-of-universe commentary).Andrews (Only appearance) (Xbox 360, PS3 and PC versions only) Chen (Only appearance) (Xbox 360, PS3 and PC versions only) Stillwell (Only appearance) (Xbox 360, PS3 and PC versions only) Electro (Max Dillon) (Only appearance) (GBA version only).Shriek (Frances Barrison) (Only appearance) (PS2, PSP and Wii versions only).Michael Morbius (Only appearance) (PS2, PSP and Wii versions only).Scorpion (MacDonald Gargan) (Last appearance) (Xbox 360, PS3 and PC versions only).Kraven The Hunter (Sergei Kravinoff) (Last appearance).Kingpin (Wilson Fisk) (Only appearance dies) (Xbox 360, PS3 and PC versions only).Mad Bomber (Luke Carlyle) (Only appearance).Calypso (Last appearance) (Xbox 360, PS3 and PC versions only).Curt Connors) (First appearance as Lizard) Rhino (Alexander O'Hirn) (Last appearance) (Xbox 360, PS3 and PC versions only).Captain Jean DeWolfe (Only appearance) (Xbox 360, PS3 and PC versions only).